Description

n-Benzyl-Dibenzazepinone-D4 is a deuterated isotopologue of a dibenzazepinone derivative, a key structural motif in pharmaceutical chemistry. This labeled compound is specifically designed for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in analytical measurements. It is essential for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors who require precise quantification of the parent compound in complex biological matrices.

Application

• Primary use as a stable isotope-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalysis.
• Critical for pharmacokinetic (PK) and toxicokinetic (TK) studies to quantify drug concentrations in plasma, serum, and tissue samples.
• Enables accurate metabolite identification and profiling in drug metabolism and disposition (DMPK) research.
• Supports method development and validation in regulatory-compliant analytical laboratories (GLP/GCP).
• Used in impurity profiling and degradation studies to monitor the stability of the non-deuterated active pharmaceutical ingredient (API).
• Facilitates clinical trial sample analysis, ensuring data integrity for regulatory submissions to agencies like the FDA and EMA.

Basic Information

Product Name	n-Benzyl-Dibenzazepinone-D4
CAS No.	1189446-39-6
Molecular Formula	C22H13D4NO
Molecular Weight	Contact for details
Synonyms	Deuterated n-Benzyl-Dibenzazepinone; Dibenzazepinone-D4, N-benzyl-; 5H-Dibenz[b,f]azepin-5-one, 10-(phenylmethyl)-, D4-; 10-Benzyl-5H-dibenzo[b,f]azepin-5-one-d4; Isotopically Labeled Dibenzazepinone; Internal Standard for LC-MS; Stable Isotope-Labeled Analytical Standard; Deuterated Pharmaceutical Intermediate
EINECS	Contact for details

Quality Control

Every batch of n-Benzyl-Dibenzazepinone-D4 is manufactured and tested to meet the exacting standards required for analytical reference materials. Our rigorous quality testing includes advanced spectroscopic and chromatographic methods to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for parameters such as assay by HPLC, isotopic enrichment by NMR or MS, and residual solvent content. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.