Description

Valdecoxib-13C2, 15N is a stable isotope-labeled analog of the selective COX-2 inhibitor valdecoxib, specifically enriched with carbon-13 and nitrogen-15. This high-purity reference standard is critical for ensuring the accuracy and reliability of quantitative mass spectrometry-based analyses in pharmaceutical research and development. It is an essential tool for scientists and quality control laboratories engaged in drug metabolism and pharmacokinetic (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of valdecoxib and its metabolites in complex biological matrices like plasma, serum, and urine.
• Bioanalytical Method Development & Validation: Used to develop, optimize, and validate robust, sensitive, and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Clinical Research & Therapeutic Drug Monitoring: Facilitates reliable measurement of drug concentrations in patient samples during clinical trials or therapeutic drug monitoring programs.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradants in active pharmaceutical ingredient (API) batches.
• Forensic and Toxicology Analysis: Supports accurate detection and quantification of valdecoxib in forensic investigations or toxicological screenings.

Basic Information

Product Name	Valdecoxib-13C2, 15N
CAS No.	1189428-23-6
Molecular Formula	C1413C2H14N15NO3S
Molecular Weight	317.33 g/mol (for labeled form)
Synonyms	4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide-13C2,15N; Valdecoxib (phenyl-13C2,15N); BEXTRA-13C2,15N; SC 65872-13C2,15N; Isotopically labeled Valdecoxib; Valdecoxib Internal Standard; [13C2,15N]-Valdecoxib
EINECS	Contact for details

Quality Control

Every batch of Valdecoxib-13C2, 15N is manufactured and analyzed under strict quality systems to ensure the highest standards of isotopic purity, chemical purity, and stability. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic techniques, to ensure compliance with the stringent requirements for analytical reference standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity (by HPLC), and other critical parameters are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C; ≥99 atom % 15N
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.