Description

Kn-93 Phosphate is a potent and selective cell-permeable inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII), a key enzyme involved in numerous cellular signaling pathways. This compound is crucial for researchers investigating cardiac function, neuronal signaling, and other physiological processes regulated by CaMKII activity. It is an essential biochemical tool for pharmaceutical R&D, academic research, and biotechnology applications focused on signal transduction and kinase biology.

Application

• Biochemical Research: Used as a selective CaMKII inhibitor to study enzyme kinetics, substrate specificity, and inhibition mechanisms in in vitro assays.
• Cardiovascular Research: Investigates the role of CaMKII in cardiac hypertrophy, arrhythmias, and heart failure models.
• Neuroscience Research: Explores CaMKII function in synaptic plasticity, memory formation, and neuronal excitability.
• Cell Signaling Studies: A key tool for dissecting calcium-mediated signaling cascades in various cell types and disease models.
• Pharmaceutical Development: Serves as a reference compound and pharmacological probe in drug discovery programs targeting kinase-related disorders.

Basic Information

Product Name	Kn-93 Phosphate
CAS No.	1188890-41-6
Molecular Formula	C₂₄H₂₇N₅O₅P
Molecular Weight	496.48 g/mol
Synonyms	KN-93 phosphate; KN93 phosphate; 2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine phosphate; CaMKII Inhibitor KN-93 phosphate; N-[2-[[[(2E)-3-(4-Chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate
EINECS	Contact for details

Quality Control

Our Kn-93 Phosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.