Description

Kn 93 is a potent and selective cell-permeable inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII), a key enzyme involved in numerous cellular signaling pathways. This compound is a critical research tool for elucidating the role of CaMKII in physiological and pathological processes, including cardiac function, neuronal signaling, and memory formation. It is essential for researchers in pharmaceutical development, academic biochemistry, and neurobiology who require high-purity biochemical reagents for target validation and mechanistic studies. Kn 93 CAS NO 1188890-40-5 is supplied with comprehensive analytical documentation to ensure experimental reproducibility.

Application

• Biochemical Research: Used as a selective pharmacological tool to inhibit CaMKII activity in cell-based assays and enzymatic studies.
• Neuroscience Studies: Investigates the role of CaMKII in synaptic plasticity, long-term potentiation (LTP), and memory-related signaling pathways.
• Cardiovascular Research: Explores CaMKII-mediated signaling in cardiac myocytes, including its implications in hypertrophy and arrhythmia.
• Pharmaceutical Screening: Serves as a reference compound in high-throughput screening campaigns for novel CaMKII modulators.
• Signal Transduction Analysis: Helps dissect complex intracellular signaling cascades where CaMKII acts as a crucial node.
• Disease Mechanism Elucidation: Aids in research on conditions where CaMKII dysregulation is implicated, such as certain neurological disorders and heart diseases.

Basic Information

Item	Detail
Product Name	Kn 93
CAS No.	1188890-40-5
Molecular Formula	C₂₄H₂₇ClN₄O₃
Molecular Weight	454.95 g/mol
Synonyms	KN-93; CaMKII Inhibitor KN93; 2-[[(2S)-3-(4-Chlorophenyl)-2-[(2-cyanophenyl)carbamoyl]propyl]amino]-N-(2-hydroxyethyl)-2-oxoacetamide; N-[2-[[[3-(4-Chlorophenyl)-2-[(2-cyanophenyl)amino]-2-oxopropyl]amino]methyl]phenyl]-2-hydroxyacetamide; CaMKII Inhibitor III; KN 93
EINECS	Contact for details

Quality Control

Our Kn 93 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing the specific results for purity, identity, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.