Description

Pi3-Kinase α Inhibitor 2Hcl is a potent and selective small molecule inhibitor targeting the alpha isoform of phosphoinositide 3-kinase (PI3Kα), a key enzyme in the PI3K/AKT/mTOR signaling pathway. This compound is crucial for researchers and developers in oncology and metabolic disease research, enabling the study of pathway dysregulation and the development of targeted therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs focused on cancer biology, drug discovery, and signal transduction studies.

Application

• Biochemical Research: Used as a selective tool compound to study the specific role of PI3Kα in cellular signaling cascades and its differential function from other PI3K isoforms.
• Oncology Drug Discovery: Serves as a reference standard and a lead compound in the development of novel targeted cancer therapies, particularly for tumors with PIK3CA mutations.
• Cell-Based Assays: Employed in in vitro studies to inhibit PI3Kα activity, allowing for the investigation of downstream effects on cell proliferation, survival, and metabolism.
• Target Validation: Critical for validating PI3Kα as a therapeutic target in various disease models, including solid tumors and metabolic disorders.
• Preclinical Studies: Utilized in animal models to evaluate the pharmacokinetics, efficacy, and safety profiles of PI3Kα inhibition.
• Mechanism of Action Studies: Helps elucidate the complex interactions within the PI3K pathway and identify potential biomarkers for patient stratification.

Basic Information

Product Name	Pi3-Kinase α Inhibitor 2Hcl
CAS No.	1188890-32-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PI3Kα Inhibitor 2Hcl; PI3K-alpha Inhibitor 2Hcl; Phosphoinositide 3-kinase alpha Inhibitor 2Hcl; PIK3CA Inhibitor 2Hcl; (S)-2-(1H-Indazol-4-yl)-6-(4-(methanesulfonyl)piperazin-1-ylmethyl)-4-morpholinothieno[3,2-d]pyrimidine dihydrochloride; GDC-0032 (free base); Taselisib (free base); RG7604 (free base)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and potency. Certificates of Analysis (COA) detailing specific test results, including assay by HPLC and impurity profiles, are available upon request. We adhere to stringent quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (in a refrigerator) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.