Description

1,5-Difluoro-3-Iodo-2-Methyl-Benzene is a high-purity, multi-functional halogenated benzene derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring fluorine and iodine substituents, makes it an exceptionally valuable intermediate for introducing specific functional groups and modulating electronic properties in target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in developing novel herbicides, fungicides, and pesticides where the difluoro and iodo groups contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic cores in electronic materials, enhancing charge transport and thermal stability.
• Cross-Coupling Reactions: The iodine atom acts as an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating custom-designed molecular scaffolds in academic and industrial R&D labs.
• Positron Emission Tomography (PET) Tracer Precursor: Potential use in synthesizing fluorinated radiotracers for medical imaging applications.

Basic Information

Product Name	1,5-Difluoro-3-Iodo-2-Methyl-Benzene
CAS No.	1188412-99-8
Molecular Formula	C7H5F2I
Molecular Weight	253.92 g/mol
Synonyms	3-Iodo-2,6-difluorotoluene; 2,6-Difluoro-3-iodotoluene; 1,5-Difluoro-3-iodo-2-methylbenzene; 2-Methyl-1,5-difluoro-3-iodobenzene; 3-Iodo-2-methyl-1,5-difluorobenzene; Benzene, 1,5-difluoro-3-iodo-2-methyl-; Toluene, 3-iodo-2,6-difluoro-
EINECS	Contact for details

Quality Control

Our 1,5-Difluoro-3-Iodo-2-Methyl-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.