Description

2-Bromo-6-Trifluoromethylnicotinonitrile is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is essential for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly due to its reactive bromine and electron-withdrawing trifluoromethyl and nitrile groups. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce complex molecular motifs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides with enhanced activity and selectivity.
• Material Science: Serves as a building block for functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Functional Group Transformation: The nitrile group can be hydrolyzed to carboxylic acids or reduced to amines, enabling diverse molecular diversification.
• Fluorine Chemistry: The trifluoromethyl group is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability in lead compounds.

Basic Information

Product Name	2-Bromo-6-Trifluoromethylnicotinonitrile
CAS No.	1187582-21-3
Molecular Formula	C7H2BrF3N2
Molecular Weight	250.00 g/mol
Synonyms	2-Bromo-6-(trifluoromethyl)nicotinonitrile; 2-Bromo-6-(trifluoromethyl)-3-cyanopyridine; 3-Cyano-2-bromo-6-(trifluoromethyl)pyridine; Nicotinonitrile, 2-bromo-6-(trifluoromethyl)-; Pyridine, 3-cyano-2-bromo-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Trifluoromethylnicotinonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.