Description

1H-Pyrrolo[2,3-B]Pyridine, 2-Cyclopropyl-5-Fluoro- is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1187449-15-5. This compound is a critical building block in modern medicinal chemistry, valued for its unique pyrrolopyridine scaffold which is integral to developing novel bioactive molecules. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the synthesis of targeted small-molecule therapeutics, particularly in oncology and antiviral drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Active Pharmaceutical Ingredient (API) Development: Serves as a critical structural component in the manufacturing process of investigational new drugs.
• Biochemical Research: Employed as a tool compound in biochemical assays to study enzyme function and cellular pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical R&D pipelines.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 2-Cyclopropyl-5-Fluoro-
CAS No.	1187449-15-5
Molecular Formula	C10H9FN2
Molecular Weight	176.19 g/mol
Synonyms	2-Cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-2-cyclopropyl-1H-pyrrolo[2,3-b]pyridine; 2-Cyclopropyl-5-fluoro-7-azaindole; 5-Fluoro-2-cyclopropyl-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 2-cyclopropyl-5-fluoro-; 1187449-15-5; 2-Cyclopropyl-5-fluoro-1H-7-azaindole
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 2-Cyclopropyl-5-Fluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants and maintaining an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.