Description

4-Methyl-3-(2-trifluoromethylbenzoyl)pyridine is a high-value, fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. This compound is prized for its unique molecular architecture, which combines a pyridine core with a trifluoromethyl-substituted benzoyl group, offering distinct electronic and steric properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly where the introduction of fluorine atoms is desired to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, especially kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced lipophilicity and biological activity.
• Material Science: Building block for creating specialty polymers, liquid crystals, and organic electronic materials that require fluorinated aromatic systems.
• Chemical Synthesis: Versatile reagent for constructing complex heterocyclic frameworks via cross-coupling reactions, nucleophilic substitutions, and cyclizations.
• Academic & Contract Research: Essential reference standard and starting material for methodological development and discovery chemistry in university and CRO laboratories.

Basic Information

Product Name	4-Methyl-3-(2-trifluoromethylbenzoyl)pyridine
CAS No.	1187167-96-9
Molecular Formula	C14H10F3NO
Molecular Weight	265.23 g/mol
Synonyms	3-(2-(Trifluoromethyl)benzoyl)-4-methylpyridine; 4-Methyl-3-(2-(trifluoromethyl)benzoyl)pyridine; 2-Trifluoromethylbenzoyl-4-methylpyridin-3-yl ketone; 4-Methyl-3-(α,α,α-trifluoro-o-toluoyl)pyridine; 3-Benzoyl-4-methylpyridine, 2'-trifluoromethyl derivative; [4-Methyl-3-pyridinyl][2-(trifluoromethyl)phenyl]methanone
EINECS	Contact for details

Quality Control

Every batch of 4-Methyl-3-(2-trifluoromethylbenzoyl)pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and reliability for your critical R&D and scale-up processes. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), identity confirmation (by NMR and IR), and levels of specific impurities. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.