Description

3,3-Difluoropyrrolidine-1-Sulfonyl Chloride is a high-value, multi-functional chemical building block primarily used in advanced organic synthesis. Its core value lies in its dual functionality, serving as both a fluorinated heterocyclic scaffold and a reactive sulfonyl chloride, enabling the efficient construction of complex molecules. This compound is critically needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly in medicinal chemistry for creating sulfonamide-based drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of biologically active sulfonamide derivatives for drug discovery and development programs.
• Medicinal Chemistry Building Block: Used to introduce the difluoropyrrolidine moiety, a privileged structure known to improve metabolic stability and membrane permeability in drug candidates.
• Agrochemical Synthesis: Employed in the research and production of advanced pesticides and herbicides that incorporate fluorinated heterocycles for enhanced efficacy.
• Chemical Biology Probe Development: Utilized to create activity-based probes and covalent inhibitors for target identification and validation in proteomics.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	3,3-Difluoropyrrolidine-1-Sulfonyl Chloride
CAS No.	1187160-31-1
Molecular Formula	C4H6ClF2NO2S
Molecular Weight	205.61 g/mol
Synonyms	1-(Chlorosulfonyl)-3,3-difluoropyrrolidine; 3,3-Difluoro-1-pyrrolidinesulfonyl chloride; 3,3-Difluoropyrrolidine Sulfonyl Chloride; 3,3-Difluoropyrrolidine-1-sulfonyl chloride; 1-Pyrrolidinesulfonyl chloride, 3,3-difluoro-; 3,3-Difluoropyrrolidine Sulfonyl Chloride; 3,3-Difluoropyrrolidine-1-Sulphonyl Chloride; 1187160-31-1
EINECS	Contact for details

Quality Control

Our 3,3-Difluoropyrrolidine-1-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical intermediate supply, with testing performed using validated analytical methods including HPLC, GC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.