Description

3,4-Dihydro-2H-1,4-Benzoxazine-7-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative of the benzoxazine heterocycle. This compound serves as a critical pharmaceutical intermediate and versatile building block in organic synthesis, enabling the introduction of the sulfonamide pharmacophore. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and plant growth regulators containing the sulfonamide functional group.
• Chemical Research: Versatile reagent for constructing complex heterocyclic systems and for introducing sulfonyl groups in medicinal chemistry programs.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Dye & Pigment Industry: Intermediate in the synthesis of specialized sulfonated dyes and colorants.

Basic Information

Item	Details
Product Name	3,4-Dihydro-2H-1,4-Benzoxazine-7-Sulfonyl Chloride
CAS No.	1186307-20-9
Molecular Formula	C8H8ClNO3S
Molecular Weight	233.67 g/mol
Synonyms	7-(Chlorosulfonyl)-3,4-dihydro-2H-1,4-benzoxazine; 1,4-Benzoxazine-7-sulfonyl chloride, 3,4-dihydro-2H-; 2H-1,4-Benzoxazine-7-sulfonyl chloride, 3,4-dihydro-; 3,4-Dihydro-2H-benzo[b][1,4]oxazine-7-sulfonyl chloride; 7-Chlorosulfonyl-3,4-dihydro-2H-1,4-benzoxazine; Benzoxazine sulfonyl chloride derivative
EINECS	Contact for details

Quality Control

Every batch of 3,4-Dihydro-2H-1,4-Benzoxazine-7-Sulfonyl Chloride is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.