Description

3,5-Difluoro-4-methoxypyridine is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring methoxy and fluorine substituents, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials that require specific fluorine-substituted aromatic systems.
• Custom Synthesis and Contract Manufacturing: Supplied to fine chemical companies for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	3,5-Difluoro-4-methoxypyridine
CAS No.	1186195-24-3
Molecular Formula	C6H5F2NO
Molecular Weight	145.11 g/mol
Synonyms	4-Methoxy-3,5-difluoropyridine; 3,5-Difluoro-4-pyridinol methyl ether; 3,5-Difluoro-4-methoxypyridine; 4-Pyridinol, 3,5-difluoro-, methyl ether; Difluoromethoxypyridine
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-methoxypyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results from HPLC, GC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.