Description

4-Bromo-1-Fluoro-2-(2,2,2-Trifluoroethyl)Benzene is a high-value, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. This compound is specifically engineered to introduce bromine, fluorine, and a trifluoroethyl moiety in a single, strategically positioned molecule, enabling precise structural modifications. It is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and pesticides, where the fluorine and trifluoroethyl groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and device efficiency.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry Research: An invaluable reagent for studying structure-activity relationships (SAR) and for introducing fluorine atoms into complex molecular architectures in academic and industrial R&D.
• Polymer Modification: Used to incorporate fluorinated aromatic units into specialty polymers, enhancing their thermal stability, chemical resistance, and surface properties.

Basic Information

Product Name	4-Bromo-1-Fluoro-2-(2,2,2-Trifluoroethyl)Benzene
CAS No.	1186195-21-0
Molecular Formula	C8H5BrF4
Molecular Weight	273.03 g/mol
Synonyms	1-Bromo-4-fluoro-2-(2,2,2-trifluoroethyl)benzene; 2-(2,2,2-Trifluoroethyl)-4-bromofluorobenzene; 4-Bromo-α,α,α-trifluoro-o-fluoroethylbenzene; [2-Bromo-5-fluorophenyl](trifluoro)methane (incorrect but common misnomer); 2-(Trifluoroethyl)-4-bromo-1-fluorobenzene; 1186195-21-0; Benzene, 4-bromo-1-fluoro-2-(2,2,2-trifluoroethyl)-
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-Fluoro-2-(2,2,2-Trifluoroethyl)Benzene is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Purity (HPLC/GC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.