Description

1-Chloro-2-Fluoro-4-(2,2,2-Trifluoroethyl)Benzene is a high-purity, multi-functional fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring both halogen and trifluoroethyl substituents, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms contribute to enhanced biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and device efficiency.
• Polymer & Specialty Chemicals: Employed as a monomer or modifier in the creation of high-performance polymers, coatings, and specialty chemicals with improved chemical resistance and thermal stability.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to the presence of a reactive chlorine atom, enabling rapid diversification of complex molecular architectures.

Basic Information

Product Name	1-Chloro-2-Fluoro-4-(2,2,2-Trifluoroethyl)Benzene
CAS No.	1186194-82-0
Molecular Formula	C8H5ClF4
Molecular Weight	212.57 g/mol
Synonyms	4-(2,2,2-Trifluoroethyl)-1-chloro-2-fluorobenzene; 2-Chloro-1-fluoro-4-(2,2,2-trifluoroethyl)benzene; 1-Chloro-2-fluoro-4-(trifluoroethyl)benzene; 4-(Trifluoroethyl)-2-chlorofluorobenzene; 2-Fluoro-5-chlorobenzotrifluoride, 4-(Trifluoroethyl) isomer; Benzene, 1-chloro-2-fluoro-4-(2,2,2-trifluoroethyl)-; CAS 1186194-82-0
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-Fluoro-4-(2,2,2-Trifluoroethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and lot-to-lot consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.