Description

1-(2-Bromo-1,1-Difluoroethyl)-2-Methoxybenzene is a specialized fluorinated and brominated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a difluoroethyl bromide moiety with a methoxybenzene ring, enabling precise structural modifications in target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex intermediates, particularly in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced pesticide and herbicide intermediates, where the difluoro and bromo groups can be critical for biological activity.
• Material Science Research: Serves as a precursor for specialty monomers or ligands in the development of novel polymers or catalysts with specific electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form carbon-carbon bonds.
• Fluorine Chemistry Exploration: An important reagent for studying the introduction and behavior of gem-difluoroalkyl groups into complex molecular frameworks.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific halogenated fluorochemical.

Basic Information

Product Name	1-(2-Bromo-1,1-Difluoroethyl)-2-Methoxybenzene
CAS No.	1186194-40-0
Molecular Formula	C9H9BrF2O
Molecular Weight	251.07 g/mol
Synonyms	2-Methoxy-1-(2-bromo-1,1-difluoroethyl)benzene; 1-(2-Bromo-1,1-difluoroethyl)-2-methoxybenzene; o-Methoxy-α-(bromodifluoromethyl)benzyl Bromide (related precursor); Benzene, 1-(2-bromo-1,1-difluoroethyl)-2-methoxy-; 2-Bromo-1,1-difluoro-1-(2-methoxyphenyl)ethane; (2-Bromo-1,1-difluoroethyl)(2-methoxyphenyl)methane
EINECS	Contact for details

Quality Control

Our 1-(2-Bromo-1,1-Difluoroethyl)-2-Methoxybenzene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports your research and development needs with reliable, high-purity materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.