Description

Acyclovir-D4 CAS NO 1185179-33-2 is a deuterium-labeled analog of the antiviral drug Acyclovir, specifically designed for use as an internal standard in quantitative analytical methods. This stable isotope-labeled compound is critical for ensuring the accuracy and reliability of mass spectrometry-based assays in pharmaceutical research and development. It is primarily utilized by analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and regulatory testing laboratories for pharmacokinetic studies, bioanalytical method development, and quality control of antiviral formulations.

Application

• Internal Standard for LC-MS/MS Analysis: Essential for the precise quantification of Acyclovir in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Metabolism Studies: Used in drug development to track absorption, distribution, metabolism, and excretion (ADME) profiles.
• Bioanalytical Method Validation: Serves as a critical reference material to validate analytical methods according to FDA, EMA, and ICH guidelines.
• Drug Impurity Profiling and Stability Testing: Aids in the identification and quantification of drug-related substances in stability-indicating assays.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and clinical trial sample analysis for antiviral therapies.
• Quality Control in Pharmaceutical Manufacturing: Ensures batch-to-batch consistency and potency of finished drug products containing Acyclovir.

Basic Information

Product Name	Acyclovir-D4
CAS No.	1185179-33-2
Molecular Formula	C8H7D4N5O3
Molecular Weight	229.23 g/mol
Synonyms	9-[(2-Hydroxyethoxy)methyl]-6H-purin-6-one-d4; 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one-d4; Acyclovir-d4; Deuterated Acyclovir; Acyclovir (D4); Acyclovir Internal Standard; [2H4]-Acyclovir; ACV-D4
EINECS	Contact for details

Quality Control

Our Acyclovir-D4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry for structural confirmation and isotopic enrichment verification, and HPLC for chemical and isotopic purity assessment. We provide a comprehensive Certificate of Analysis (COA) detailing all specifications, including chemical purity, isotopic purity (atom % D), and residual solvent content, ensuring compliance with the stringent requirements of analytical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity (by NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.