Description

Bicalutamide-D4 CAS NO 1185035-71-5 is a deuterated analog of the non-steroidal anti-androgen bicalutamide, where four hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in mass spectrometry. It is a critical material for pharmaceutical research and development, clinical laboratories, and contract research organizations (CROs) focused on metabolism studies, pharmacokinetic analysis, and drug monitoring.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in the quantitative analysis of bicalutamide and its metabolites in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Used in stable isotope dilution assays to study the absorption, distribution, metabolism, and excretion (ADME) profile of bicalutamide.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Enables precise measurement of drug concentrations in patient samples to optimize dosing regimens for prostate cancer treatment.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of deuterated impurities or related substances in active pharmaceutical ingredient (API) batches.
• Bioanalytical Method Development & Validation: Provides a stable, non-interfering isotopic standard for developing robust, sensitive, and specific analytical protocols.
• Forensic & Anti-Doping Analysis: Supports accurate detection and confirmation of bicalutamide in forensic toxicology and sports doping control programs.

Basic Information

Product Name	Bicalutamide-D4
CAS No.	1185035-71-5
Molecular Formula	C18H10D4F4N2O4S
Molecular Weight	430.40 g/mol (for deuterated form)
Synonyms	Bicalutamide-d4; [D4]-Bicalutamide; N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl-d4)sulfonyl]-2-hydroxy-2-methylpropanamide; Casodex-d4; Deuterated Bicalutamide; Bicalutamide Internal Standard; Bicalutamide Isotopic Label; Bicalutamide Stable Isotope
EINECS	Contact for details

Quality Control

Our Bicalutamide-D4 is manufactured under strict quality systems to ensure the isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as isotopic enrichment (D-content), chemical purity by HPLC, and identity confirmation by spectroscopic methods. We adhere to relevant industry guidelines for reference standards to support your GLP/GMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.