Description

Benzylhydrochlorothiazide-D5 is a deuterated analog of the thiazide diuretic benzylhydrochlorothiazide, where five hydrogen atoms are replaced with the stable isotope deuterium. This compound is a critical internal standard and reference material for the precise quantification of benzylhydrochlorothiazide in complex matrices using advanced analytical techniques like LC-MS/MS and GC-MS. It is essential for pharmaceutical research and development, clinical laboratories, and forensic toxicology, where accurate and reliable analytical data is paramount for method validation, pharmacokinetic studies, and quality control.

Application

• Internal Standard for Mass Spectrometry: Serves as a stable isotope-labeled internal standard for the accurate quantification of benzylhydrochlorothiazide in bioanalytical assays (plasma, serum, urine).
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the parent drug and its metabolites.
• Clinical Research & Toxicology: Enables precise measurement in therapeutic drug monitoring (TDM) and forensic analysis.
• Method Development & Validation: Critical for developing and validating robust, high-sensitivity analytical methods in compliance with regulatory guidelines (FDA, EMA).
• Reference Material: Acts as a certified reference material (CRM) for instrument calibration and ensuring analytical accuracy.
• Metabolite Identification: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.

Basic Information

Product Name	Benzylhydrochlorothiazide-D5
CAS No.	1185024-05-8
Molecular Formula	C15H9D5ClN3O4S2
Molecular Weight	~ 388.88 g/mol
Synonyms	Benzyl Hydrochlorothiazide-D5; 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 3-(phenylmethyl)-, D5; 3-Benzyl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-D5; Deuterated Benzylhydrochlorothiazide; [D5]-Benzylhydrochlorothiazide; Benzyl HCTZ-D5; Stable Isotope Labeled Benzylhydrochlorothiazide
EINECS	Contact for details

Quality Control

Our Benzylhydrochlorothiazide-D5 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for analytical applications. Each batch is characterized using NMR (¹H, ¹³C), High-Resolution Mass Spectrometry (HRMS), and HPLC to confirm chemical structure, isotopic enrichment (typically ≥98 atom % D), and chemical purity (typically ≥95%). A comprehensive Certificate of Analysis (COA) detailing all analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.