Description

2-Fluoro-4-Hydroxy-3-Methoxypyridine is a high-value, multi-functional heterocyclic building block used in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise molecular design. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its electron-donating and accepting capabilities.
• Chemical Biology Probes: Utilized to create fluorescent tags or molecular probes for studying biological processes and enzyme mechanisms.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	2-Fluoro-4-Hydroxy-3-Methoxypyridine
CAS No.	1184172-38-0
Molecular Formula	C6H6FNO2
Molecular Weight	143.12 g/mol
Synonyms	3-Methoxy-2-fluoro-4-hydroxypyridine; 2-Fluoro-3-methoxy-4-pyridinol; 4-Hydroxy-3-methoxy-2-fluoropyridine; 2-Fluoro-4-pyridinol, 3-methoxy-; 1184172-38-0; FC1(OC)=C(O)C=NC=1
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Hydroxy-3-Methoxypyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.