Description

5-Methyl-1H-Pyrazole-4-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative used as a critical building block in advanced organic synthesis. Its primary value lies in its ability to introduce the 5-methyl-1H-pyrazole-4-sulfonyl moiety, a key functional group for modulating biological activity and physicochemical properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the pyrazole sulfonamide scaffold is prevalent.
• Chemical Biology & Proteomics: Serves as a reactive handle for activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Material Science Research: Employed in the synthesis of functional polymers and advanced materials with specific sulfonamide linkages.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Methyl-1H-Pyrazole-4-Sulfonyl Chloride
CAS No.	1179918-36-5
Molecular Formula	C4H5ClN2O2S
Molecular Weight	180.61 g/mol
Synonyms	5-Methyl-1H-pyrazole-4-sulfonyl chloride; 4-Pyrazolesulfonyl chloride, 5-methyl-1H-; 1H-Pyrazole-4-sulfonyl chloride, 5-methyl-; 5-Methyl-1H-4-pyrazolesulfonyl chloride; 5-Methyl-4-sulfonylchloride-1H-pyrazole; 5-Methylpyrazole-4-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 5-Methyl-1H-Pyrazole-4-Sulfonyl Chloride is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) specifying purity (typically ≥95% by HPLC), identity, and impurity profile is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.