Description

4-(2,2-Difluoroethoxy)-3-Methoxybenzaldehyde is a specialized aromatic aldehyde derivative featuring a difluoroethoxy substituent, serving as a high-value synthetic intermediate. This compound is critical for pharmaceutical and advanced material research, where its unique fluorine-containing side chain enables precise modulation of molecular properties. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and liquid crystal industries for constructing complex target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and fungicides, where the difluoroethoxy group can enhance bioavailability and environmental stability.
• Liquid Crystal Materials: A valuable precursor for creating fluorine-containing liquid crystal compounds used in high-performance displays (LCDs).
• Organic Electronics: Serves as a starting material for synthesizing specialized organic semiconductors and charge-transport materials.
• Fluorine Chemistry Research: An important substrate for studying the effects of fluorine substitution on reaction kinetics and molecular conformation in academic and industrial R&D.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	4-(2,2-Difluoroethoxy)-3-Methoxybenzaldehyde
CAS No.	1179127-75-3
Molecular Formula	C10H10F2O3
Molecular Weight	216.18 g/mol
Synonyms	3-Methoxy-4-(2,2-difluoroethoxy)benzaldehyde; Benzaldehyde, 4-(2,2-difluoroethoxy)-3-methoxy-; 4-(Difluoroethoxyl)-3-methoxybenzaldehyde; Vanillin difluoroethyl ether; DFE-protected Vanillin derivative; 2,2-Difluoroethyl 3-methoxy-4-formylphenyl ether
EINECS	Contact for details

Quality Control

Our 4-(2,2-Difluoroethoxy)-3-Methoxybenzaldehyde is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.