Description

3-Nitro-4-(Trifluoroacetamido)Benzene-1-Sulfonyl Chloride is a high-purity, specialized sulfonyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its molecular architecture, featuring both a reactive sulfonyl chloride group and a protected amine, makes it an indispensable intermediate for constructing complex molecules with specific functionalities. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and sophisticated dyes or pigments.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, potentially for use as enzyme inhibitors or receptor antagonists.
• Agrochemical Research: Used in creating novel herbicides, fungicides, or insecticides where the sulfonamide moiety can confer specific biological activity.
• Dye and Pigment Chemistry: Serves as a building block for synthesizing complex azo dyes or specialty pigments with enhanced properties.
• Material Science: Can be utilized in the development of advanced polymers or functional materials requiring sulfonamide linkages.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes due to its reactive handles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific, multi-step synthetic routes.

Basic Information

Product Name	3-Nitro-4-(Trifluoroacetamido)Benzene-1-Sulfonyl Chloride
CAS No.	1178647-96-5
Molecular Formula	C8H4ClF3N2O5S
Molecular Weight	332.64 g/mol
Synonyms	4-(Trifluoroacetamido)-3-nitrobenzenesulfonyl chloride; 3-Nitro-4-trifluoroacetamidobenzenesulfonyl chloride; N-[2-Nitro-4-(chlorosulfonyl)phenyl]-2,2,2-trifluoroacetamide; 2-Nitro-4-(chlorosulfonyl)trifluoroacetanilide; 4-Amino-3-nitrobenzenesulfonyl chloride, N-trifluoroacetyl-; Benzenesulfonyl chloride, 4-[(trifluoroacetyl)amino]-3-nitro-; TFA-protected 4-amino-3-nitrobenzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Nitro-4-(Trifluoroacetamido)Benzene-1-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to guarantee the reliability and traceability of our products for the global B2B market.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to prevent decomposition. Keep away from incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.