Description

Cyclopamine Tartrate CAS NO 1178510-81-0 is a high-purity, steroidal alkaloid derivative known for its potent and specific inhibition of the Hedgehog (Hh) signaling pathway. This targeted mechanism makes it an invaluable research-grade biochemical for investigating developmental biology, stem cell regulation, and oncogenesis. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer research and regenerative medicine.

Application

• Biomedical Research: A critical tool for studying the Hedgehog signaling pathway's role in cell differentiation, proliferation, and tissue patterning.
• Oncology Studies: Used in vitro and in vivo to inhibit Hh-dependent tumor growth, making it essential for cancer mechanism research and preclinical drug discovery.
• Stem Cell Research: Employed to modulate stem cell fate and self-renewal by selectively blocking the Hh pathway.
• Developmental Biology: Serves as a reference compound for investigating congenital disorders and embryonic development linked to Hh signaling.
• Biochemical Assay Standard: Used as a reference standard in high-throughput screening (HTS) and assay development for identifying novel Hh pathway inhibitors.
• Pharmacology & Toxicology: Applied in ADME (Absorption, Distribution, Metabolism, Excretion) and safety pharmacology studies for compounds targeting similar pathways.

Basic Information

Product Name	Cyclopamine Tartrate
CAS No.	1178510-81-0
Molecular Formula	C₂₇H₄₁NO₂ • C₄H₆O₆
Molecular Weight	627.77 g/mol
Synonyms	11-Deoxojervine Tartrate; (3β,23R)-17,23-Epoxy-11-deoxoveratraman-3-ol Tartrate; 11-Deoxyjervine Tartrate; Cyclopamine Hemitartrate; Jervine derivative tartrate; 3β-Hydroxy-11-deoxojervine Tartrate; Veratrum alkaloid tartrate salt
EINECS	Contact for details

Quality Control

Our Cyclopamine Tartrate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research chemicals, ensuring reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.