Description

2,6-Difluoro-4-Methoxybenzenesulfonylchloride is a high-value, multi-functional chemical building block characterized by its reactive sulfonyl chloride group and strategically placed fluorine and methoxy substituents. This compound is essential for the synthesis of complex molecules, particularly in the development of advanced active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for creating novel sulfonamides and other derivatives with tailored biological and physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including potential enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides where the difluoro-methoxy benzene scaffold imparts specific bioactivity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Chemical Biology Probes: Employed in the creation of activity-based probes and affinity labels for studying enzyme function and protein interactions.
• Dye and Pigment Intermediate: Acts as a building block for synthesizing specialized dyes and pigments with unique colorfastness and spectral properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring this specific sulfonyl chloride derivative.

Basic Information

Product Name	2,6-Difluoro-4-Methoxybenzenesulfonylchloride
CAS No.	1178498-86-6
Molecular Formula	C7H5ClF2O3S
Molecular Weight	242.63 g/mol
Synonyms	4-Methoxy-2,6-difluorobenzenesulfonyl chloride; 2,6-Difluoro-4-methoxybenzene-1-sulfonyl chloride; 2,6-Difluoro-4-methoxybenzenesulfonyl chloride; 1-(Chlorosulfonyl)-2,6-difluoro-4-methoxybenzene; Benzenesulfonyl chloride, 2,6-difluoro-4-methoxy-; 2,6-Difluoro-4-methoxybenzene sulfonyl chloride; 2,6-Difluoro-4-methoxy-phenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-4-Methoxybenzenesulfonylchloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	≥ 96.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.