Description

Nsc 23766 (Hydrochloride) is a high-purity, small-molecule chemical compound supplied as a hydrochloride salt. This product is a valuable research-grade inhibitor primarily used in biochemical and pharmacological studies to investigate specific cellular signaling pathways. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors who require reliable, well-characterized compounds for target validation and drug discovery efforts. The compound is identified by CAS NO 1177865-17-6.

Application

• Biochemical Research: Used as a potent and selective inhibitor of Rac1 GTPase activation in cell signaling studies.
• Pharmacological Studies: A key tool compound for investigating the role of Rac-mediated pathways in various disease models, including cancer and neurological disorders.
• Drug Discovery: Employed in high-throughput screening (HTS) and target validation assays to identify and characterize new therapeutic candidates.
• Academic Research: Utilized in university and institutional labs for fundamental research into cytoskeletal dynamics, cell migration, and proliferation.
• Preclinical Development: Serves as a reference standard in the development of novel Rac1-targeted therapies.

Basic Information

Product Name	Nsc 23766 (Hydrochloride)
CAS No.	1177865-17-6
Molecular Formula	C₂₀H₂₈ClN₅O₃ • HCl
Molecular Weight	458.38 g/mol (as hydrochloride salt)
Synonyms	NSC 23766; NSC-23766; NSC23766; Rac1 Inhibitor; 1,2,3,4-Tetrahydro-1-[(6,7-dimethoxy-2-methyl-4-quinazolinyl)methyl]-7-[(4-pyridinylmethyl)amino]-isoquinoline dihydrochloride; 6,7-Dimethoxy-2-methyl-1-[(1,2,3,4-tetrahydroisoquinolin-7-ylamino)methyl]-4-quinazolinamine dihydrochloride; Rac GTPase Inhibitor
EINECS	Contact for details

Quality Control

Our Nsc 23766 (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.