Description

L-744,832 is a potent and selective small molecule inhibitor of the farnesyltransferase enzyme, a key target in oncology and cell signaling research. This compound is crucial for studying the role of protein prenylation in cancer cell proliferation, particularly in Ras-driven tumor models. Researchers in pharmaceutical R&D and academic institutions utilize L-744,832 CAS NO 1177806-11-9 to investigate novel therapeutic pathways and validate drug targets.

Application

• Oncology Research: Used as a key pharmacological tool to inhibit farnesyltransferase and study its role in Ras oncogene signaling and tumorigenesis.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel anti-cancer therapeutics targeting protein prenylation.
• Biochemical Assays: Employed in in vitro enzymatic assays to screen for and characterize new farnesyltransferase inhibitors.
• Cell Biology Studies: Applied in cell culture models to investigate the effects of disrupted protein localization and function on cell growth and morphology.
• Signal Transduction Research: A critical reagent for dissecting the prenylation-dependent pathways involved in cellular communication and disease progression.

Basic Information

Product Name	L-744,832
CAS No.	1177806-11-9
Molecular Formula	C27H30N4O4S
Molecular Weight	506.62 g/mol
Synonyms	Farnesyltransferase Inhibitor I; (S)-6-[Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; L 744832; L744832; SCH 66336 analog
EINECS	Contact for details

Quality Control

Our L-744,832 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.