Description

Sphingosine Kinase Inhibitor CAS NO 1177741-83-1 is a potent and selective small molecule inhibitor of sphingosine kinase (SphK), a key enzyme in the sphingolipid metabolic pathway. This compound is a critical research tool for investigating the role of sphingosine-1-phosphate (S1P) signaling in cellular processes and disease states. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, immunology, and inflammatory disease research.

Application

• Biomedical Research: A fundamental tool for studying the S1P signaling pathway, its role in cell proliferation, survival, and migration.
• Oncology Research: Investigation of novel cancer therapeutics by targeting SphK, which is often upregulated in various tumors.
• Immunology & Inflammation Studies: Research into autoimmune diseases, allergic responses, and inflammatory conditions modulated by S1P.
• Cardiovascular Research: Exploration of S1P's effects on endothelial function, vascular integrity, and heart disease.
• Neurological Disorder Research: Study of SphK/S1P axis involvement in neuroinflammation, multiple sclerosis, and other CNS pathologies.
• Preclinical Drug Discovery: Used as a reference standard or lead compound in high-throughput screening and hit-to-lead optimization campaigns.

Basic Information

Item	Detail
Product Name	Sphingosine Kinase Inhibitor
CAS No.	1177741-83-1
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	SKI-II; 2-(p-Hydroxyanilino)-4-(p-hydroxyphenyl)thiazole; (E)-N-Ethyl-2-((4-(4-(pyridin-4-yl)phenyl)thiazol-2-yl)methylene)hydrazinecarboxamide; Sphingosine Kinase 1 Inhibitor II; SphK1 Inhibitor; PF-543 analog (research compound)
EINECS	Contact for details

Quality Control

Our Sphingosine Kinase Inhibitor is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.