Description

Dextromethorphan n-Oxide Hydrochloride is a high-purity pharmaceutical intermediate and analytical reference standard. This compound is critical for research and development in neuropharmacology and for ensuring the quality control of related active pharmaceutical ingredients. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism studies, impurity profiling, and method development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor or metabolite in the development and production of dextromethorphan-based active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for the identification, assay, and impurity quantification of dextromethorphan and related compounds in drug substances and finished products via HPLC, LC-MS, or GC-MS.
• Metabolite Studies: Serves as a critical standard in pharmacokinetic and drug metabolism research to understand the biotransformation pathways of dextromethorphan.
• Impurity Profiling: Employed to qualify and control process-related impurities and degradation products in accordance with ICH Q3A and Q3B guidelines.
• Method Development & Validation: Essential for developing and validating robust analytical methods for quality control laboratories.
• Neuroscience Research: Used as a tool compound in preclinical research to study NMDA receptor antagonism and related neurological mechanisms.

Basic Information

Product Name	Dextromethorphan n-Oxide Hydrochloride
CAS No.	1177419-85-0
Molecular Formula	C18H26ClNO2
Molecular Weight	323.86 g/mol
Synonyms	Dextromethorphan N-Oxide HCl; (+)-3-Methoxy-17-methyl-9α,13α,14α-morphinan N-Oxide Hydrochloride; Dextromethorphan N-Oxide Hydrochloride Salt; Dextromethorphan N-Oxide Monohydrochloride; DXM N-Oxide HCl; 1,2,3,9,10,10a-Hexahydro-6-methoxy-4H-10,4a-(iminoethano)phenanthrene N-Oxide Hydrochloride
EINECS	Contact for details

Quality Control

Our Dextromethorphan n-Oxide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profile analysis, to ensure it meets the high-purity standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.