Description

(+)-Blebbistatin CAS NO 1177356-70-5 is a highly potent and selective cell-permeable inhibitor of non-muscle myosin II ATPase activity. This compound matters for its critical role in modulating cellular contractility, making it an indispensable tool for cytoskeleton and cell mechanics research. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cell biology, neurobiology, and cardiovascular disease studies.

Application

• Cytoskeleton Research: Selective inhibition of non-muscle myosin II to study actomyosin contractility, cell division (cytokinesis), and cell migration.
• Neuroscience Studies: Investigation of neurite outgrowth, growth cone dynamics, and synaptic plasticity by modulating neuronal contractility.
• Cardiovascular Research: Exploration of cardiac myocyte contractility and the role of non-muscle myosin II in heart development and disease models.
• Cell Mechanics & Biophysics: A key reagent for studies on cellular tension, mechanotransduction, and tissue morphogenesis.
• Oncology Research: Used to probe the role of myosin II in cancer cell invasion, metastasis, and tumor microenvironment interactions.
• High-Content Screening (HCS): Employed as a reference compound in phenotypic screening assays targeting the cytoskeleton.

Basic Information

Item	Detail
Product Name	(+)-Blebbistatin
CAS No.	1177356-70-5
Molecular Formula	C18H16N2O3
Molecular Weight	308.33 g/mol
Synonyms	(+)-Blebbistatin; (S)-Blebbistatin; Blebbistatin enantiomer; (-)-Blebbistatin (incorrect but common alias); 3-((S)-1,2-Dihydro-1-hydroxy-2-oxo-5H-pyrido[2,3-b][1,4]benzoxazepin-8-yl)-4-hydroxy-1-methyl-2(1H)-quinolinone; Myosin II inhibitor; NMII inhibitor
EINECS	Contact for details

Quality Control

Our (+)-Blebbistatin is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for life science research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. For long-term storage, keep desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.