Description

2-Fluoro-4-(Trifluoromethyl)Benzenesulfonyl Chloride is a high-value, multi-functional chemical intermediate prized for its unique trifluoromethyl and sulfonyl chloride functional groups. This compound is critical for introducing specific fluorinated aromatic motifs into target molecules, enabling the fine-tuning of their physical, chemical, and biological properties. It is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical sectors for the synthesis of advanced active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance bioavailability and environmental stability.
• Material Science: Serves as a precursor for functional polymers, liquid crystals, and advanced coatings, leveraging its sulfonyl chloride group for polymerization or surface modification.
• Chemical Research & Development: An essential reagent in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of compound libraries for high-throughput screening.
• Dye and Pigment Manufacturing: Employed in the synthesis of specialized fluorinated dyes and pigments that offer superior lightfastness and chemical resistance.

Basic Information

Item	Details
Product Name	2-Fluoro-4-(Trifluoromethyl)Benzenesulfonyl Chloride
CAS No.	1177009-38-9
Molecular Formula	C7H3ClF4O2S
Molecular Weight	262.61 g/mol
Synonyms	2-Fluoro-α,α,α-trifluoro-p-toluenesulfonyl chloride; 4-(Trifluoromethyl)-2-fluorobenzenesulfonyl chloride; 2-Fluoro-4-trifluoromethylbenzenesulfonyl chloride; 2-Fluoro-α,α,α-trifluoro-4-methylbenzenesulfonyl chloride; 2-Fluoro-4-(trifluoromethyl)phenylsulfonyl chloride; 4-Trifluoromethyl-2-fluorobenzenesulfonyl chloride; 2-Fluoro-4-(trifluoromethyl)benzene-1-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-(Trifluoromethyl)Benzenesulfonyl Chloride is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and GC analysis, to ensure compliance with industry standards and customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available upon request for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.