Description

5-(Difluoromethoxy)Picolinic Acid is a high-purity, fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a difluoromethoxy group attached to the picolinic acid scaffold, makes it a valuable intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating new molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve lipophilicity and biological efficacy.
• Ligand for Catalysis: Potential application as a precursor for specialized ligands in transition metal catalysis, useful in cross-coupling and other synthetic transformations.
• Material Science Research: Employed in the synthesis of functionalized organic materials and metal-organic frameworks (MOFs) for specialized applications.
• Chemical Biology Probes: Serves as a building block for synthesizing molecular probes used to study biological processes and enzyme functions.

Basic Information

Product Name	5-(Difluoromethoxy)Picolinic Acid
CAS No.	1174323-34-2
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	5-(Difluoromethoxy)pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 5-(difluoromethoxy)-; Picolinic acid, 5-(difluoromethoxy)-; 5-(Difluoromethoxy)-2-pyridinecarboxylic acid; 5-(Difluoromethoxy)-2-picolinic acid
EINECS	Contact for details

Quality Control

Our 5-(Difluoromethoxy)Picolinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.