Description

2-Oxo-2H-Indole-5-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative of isatin, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to act as a versatile electrophilic reagent for introducing the 2-oxoindole-5-sulfonyl moiety, enabling the construction of complex molecules with targeted functionalities. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Peptide Mimetics & Conjugation: Facilitates the sulfonylation of amines in peptides and proteins for labeling, stabilization, or creating peptide-based drugs.
• Material Science Research: Building block for synthesizing organic semiconductors, dyes, and polymers with specific electronic or optical properties.
• Chemical Biology Probes: Employed to create activity-based probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthesis projects requiring this specialized reagent.

Basic Information

Product Name	2-Oxo-2H-Indole-5-Sulfonyl Chloride
CAS No.	1174006-95-1
Molecular Formula	C8H4ClNO3S
Molecular Weight	229.64 g/mol
Synonyms	5-Indolesulfonyl chloride, 2,3-dihydro-2-oxo-; Isatin-5-sulfonyl chloride; 2,3-Dihydro-2-oxo-1H-indole-5-sulfonyl chloride; 1H-Indole-5-sulfonyl chloride, 2,3-dihydro-2-oxo-; 2-Oxoindoline-5-sulfonyl chloride; 2,3-Dioxoindoline-5-sulfonyl chloride (related); 5-Sulfochloridoisatin
EINECS	Contact for details

Quality Control

Our 2-Oxo-2H-Indole-5-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.