Description

1,7-Dimethyluric Acid-2,4,5,6-13C4-1,3,9-15N3 is a high-purity, multi-isotope labeled internal standard critical for advanced quantitative bioanalytical research. This compound provides unmatched specificity and accuracy in mass spectrometry-based assays, enabling precise measurement of its non-labeled counterpart in complex biological matrices. It is an essential tool for pharmaceutical R&D, clinical research, and forensic toxicology laboratories focused on purine metabolism, drug metabolite profiling, and biomarker validation.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable isotope-labeled internal standard (SIL-IS) for the accurate quantification of 1,7-dimethyluric acid in biological samples, correcting for matrix effects and instrument variability.
• Pharmacokinetic and Drug Metabolism Studies: Enables precise tracking of drug metabolites derived from methylxanthines (e.g., caffeine, theophylline) in plasma, urine, and tissue samples.
• Clinical Diagnostics and Biomarker Research: Used in developing high-sensitivity assays for purine metabolism disorders, oxidative stress markers, and related clinical conditions.
• Forensic and Doping Control Analysis: Provides definitive identification and quantification of purine derivatives in forensic toxicology and anti-doping programs.
• Method Development and Validation: Essential for establishing and validating robust, regulatory-compliant (FDA, EMA) bioanalytical methods in GLP/GMP environments.
• Isotope Dilution Analysis: The gold-standard technique for achieving highest accuracy in trace-level quantification of analytes in complex samples.

Basic Information

Product Name	1,7-Dimethyluric Acid-2,4,5,6-13C4-1,3,9-15N3
CAS No.	1173023-17-0
Molecular Formula	C513C4H8N215N3O3
Molecular Weight	~214.11 g/mol (exact mass varies with isotopic enrichment)
Synonyms	1,7-Dimethyluric Acid-13C4,15N3; 1,7-Dimethyluric Acid (13C4,15N3); [13C4,15N3]-1,7-Dimethyluric Acid; 1,3,7-Trimethyluric Acid-2,4,5,6-13C4-1,3,9-15N3 (related); Isotopically Labeled 1,7-DMU; Stable Isotope Labeled Internal Standard for 1,7-DMU; 1,7-Dimethyl-2,6,8-trioxopurine-13C4,15N3; [2,4,5,6-13C4,1,3,9-15N3]-1,7-Dimethyluric Acid
EINECS	Contact for details

Quality Control

Every batch of 1,7-Dimethyluric Acid-2,4,5,6-13C4-1,3,9-15N3 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity verified by advanced spectroscopic and chromatographic techniques, including NMR (1H, 13C), HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay, isotopic enrichment, and impurity profiles to ensure suitability for sensitive analytical applications. Our quality commitment supports research requiring traceability and reliability in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (LC-MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (chemical purity)
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 98 atom % 15N
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.