Description

Acepromazine-D6 Hydrochloride CAS NO 1173022-70-2 is a deuterated analog of the phenothiazine derivative acepromazine, specifically labeled with six deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative analytical methods, ensuring unparalleled accuracy and reliability in mass spectrometry-based assays. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of acepromazine in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used in confirmatory testing for acepromazine in cases of suspected overdose or doping control in veterinary sports.
• Veterinary Pharmaceutical Analysis: Supports quality control and stability testing of acepromazine-containing veterinary sedative formulations.
• Metabolite Identification and Profiling: Aids in the detection and structural elucidation of acepromazine metabolites in in vitro and in vivo studies.
• Method Development and Validation: Serves as a key reference material for developing robust, compliant analytical methods according to FDA, EMA, and ICH guidelines.

Basic Information

Product Name	Acepromazine-D6 Hydrochloride
CAS No.	1173022-70-2
Molecular Formula	C19H16D6ClN2OS • HCl
Molecular Weight	~ 381.36 g/mol
Synonyms	2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine-D6 Hydrochloride; Acepromazine-d6 HCl; Deuterated Acepromazine Hydrochloride; 10-[3-(Dimethylamino)propyl]phenothiazin-2-yl methyl ketone-d6 hydrochloride; (±)-Acepromazine-d6 Maleate Salt (related salt form); NSC 134434-d6 (Hydrochloride); Atravet-d6 HCl
EINECS	Contact for details

Quality Control

Our Acepromazine-D6 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C) and Mass Spectrometry for structural confirmation and isotopic purity assessment. Purity is determined via HPLC with stringent control of chemical and isotopic impurities. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for identity, assay, purity, and residual solvents is provided with every shipment to ensure traceability and support your regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.