Description

Tetramisole-D5 Hydrochloride is a deuterated isotopologue of the anthelmintic agent tetramisole, specifically labeled with five deuterium atoms. This high-purity reference standard is critical for ensuring accurate and reliable results in quantitative analytical methods, particularly mass spectrometry. It is primarily utilized by research institutions and pharmaceutical quality control laboratories for method development, validation, and as an internal standard in pharmacokinetic and metabolic studies.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering internal standard for the precise quantification of tetramisole or levamisole in complex biological matrices like plasma, urine, and tissue homogenates.
• Metabolite Tracing & Pharmacokinetics: Enables detailed studies of drug metabolism, absorption, distribution, and excretion (ADME) using deuterium labeling to differentiate the compound from endogenous substances.
• Veterinary Pharmaceutical Analysis: Used in the quality control and residue testing of veterinary formulations to ensure accurate dosing and compliance with regulatory limits.
• Forensic & Doping Control: Supports the detection and confirmation of levamisole, often used as an adulterant in illicit drugs, in forensic toxicology and anti-doping programs.
• Method Development & Validation: Essential for developing, optimizing, and validating sensitive and specific analytical methods in compliance with guidelines like ICH Q2(R1).
• Stable Isotope Dilution Assays: Provides the foundation for highly accurate stable isotope dilution mass spectrometry (SID-MS) techniques, minimizing matrix effects and improving data reliability.

Basic Information

Product Name	Tetramisole-D5 Hydrochloride
CAS No.	1173021-85-6
Molecular Formula	C11H7D5N2S • HCl
Molecular Weight	247.80 g/mol (for C11H7D5N2S • HCl)
Synonyms	Levamisole-D5 Hydrochloride; (S)-(-)-Tetramisole-D5 Hydrochloride; (S)-2,3,5,6-Tetrahydro-6-phenyl-D5-imidazo[2,1-b]thiazole Hydrochloride; Tetramisole-d5 HCl; Deuterated Tetramisole HCl; Tetramisole (phenyl-D5) Hydrochloride
EINECS	Contact for details

Quality Control

Our Tetramisole-D5 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical reference standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chromatographic purity, and identity confirmation via spectroscopic methods. We are committed to supplying materials that meet the rigorous standards of pharmaceutical research and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D5)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.