Description

4-Fluoropicolinamide is a high-purity fluorinated heterocyclic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the fluorine atom and picolinamide moiety are crucial for modulating biological activity and physicochemical properties. It is primarily needed by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and specialty chemical sectors focused on creating new molecules with enhanced efficacy and patentability.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for improved metabolic stability and bioavailability.
• Chemical Biology Probe: Serves as a versatile scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science Precursor: Can be utilized in the synthesis of specialized ligands for catalysis or fluorinated polymers with unique properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated heterocycles.

Basic Information

Product Name	4-Fluoropicolinamide
CAS No.	1172938-55-4
Molecular Formula	C6H5FN2O
Molecular Weight	140.12 g/mol
Synonyms	4-Fluoropyridine-2-carboxamide; 2-Pyridinecarboxamide, 4-fluoro-; 4-Fluoro-2-pyridinecarboxamide; 4-Fluoropicolinic acid amide; Picolinamide, 4-fluoro-; 4-Fluoropyridine-2-carboxylic acid amide; 4-Fluoro-2-carbamoylpyridine; 1172938-55-4
EINECS	Contact for details

Quality Control

Our 4-Fluoropicolinamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is provided with each shipment to guarantee traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.