Description

Xl413 (Bms-863233) CAS NO 1169562-71-3 is a potent and selective small molecule inhibitor of the cell division cycle 7 (Cdc7) kinase, a key regulator of DNA replication initiation. This compound is a critical research tool for investigating cell cycle progression, DNA replication stress, and the development of targeted cancer therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology and molecular biology.

Application

• Biochemical Research: Used as a selective Cdc7 kinase inhibitor to study DNA replication mechanisms and cell cycle checkpoints in vitro.
• Oncology Drug Discovery: Serves as a lead compound or reference standard in the development of novel anti-cancer agents targeting DNA replication.
• Cellular Mechanism Studies: Employed to induce and study replication stress, cell cycle arrest, and apoptosis in various cancer cell lines.
• Target Validation: A key pharmacological tool for validating the Cdc7 kinase as a therapeutic target in preclinical cancer models.
• High-Throughput Screening (HTS): Utilized as a control or reference compound in screening assays designed to identify new kinase inhibitors.
• Signal Transduction Research: Helps elucidate the downstream signaling pathways and biological consequences of Cdc7 kinase inhibition.

Basic Information

Product Name	Xl413 (Bms-863233)
CAS No.	1169562-71-3
Molecular Formula	C₂₆H₂₉N₅O₃
Molecular Weight	459.54 g/mol
Synonyms	BMS-863233; XL413; (S)-N-(5-((2,3-Dihydro-1H-inden-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-3-methylpiperidine-1-carboxamide; Cdc7 Kinase Inhibitor XL413; 4-[[3-[(3S)-3-Methyl-1-piperidinyl]carbonyl]-1H-pyrazolo[3,4-d]pyrimidin-5-yl]amino]-2,3-dihydro-1H-indene; BMS 863233; XL-413
EINECS	Contact for details

Quality Control

Every batch of Xl413 (Bms-863233) is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with standards suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.