Description

2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)Pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated and heterocyclic compounds with potential therapeutic activity.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, where the trifluoromethyl and pyridine motifs are common for enhancing biological activity and environmental stability.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials that require specific fluorine and boron incorporation.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed coupling with various aryl/heteroaryl halides, enabling efficient library synthesis for drug discovery.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes, leveraging its stability and reactivity.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke, high-value compounds for client projects.

Basic Information

Product Name	2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)Pyridine
CAS No.	1169459-44-2
Molecular Formula	C12H14BF4NO2
Molecular Weight	291.05 g/mol
Synonyms	2-Fluoro-6-(trifluoromethyl)pyridine-4-boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[6-(trifluoromethyl)-2-fluoropyridin-4-yl]-1,3,2-dioxaborolane; 2-Fluoro-6-trifluoromethylpyridine-4-boronic acid pinacol ester; 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-2-fluoropyridine-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-6-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to relevant industry guidelines to support our customers' R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.