Description

1-Bromo-2-(Difluoromethyl)-3-Fluorobenzene is a high-purity, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique substitution pattern, which introduces both bromine and fluorine atoms in close proximity, enabling selective cross-coupling and further functionalization. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials industries for developing novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides where fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorine Chemistry Research: An important reagent in academic and industrial labs for studying nucleophilic aromatic substitution and other reactions specific to polyfluorinated arenes.
• Polymer Modification: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, or unique surface properties.

Basic Information

Product Name	1-Bromo-2-(Difluoromethyl)-3-Fluorobenzene
CAS No.	1166820-46-7
Molecular Formula	C7H4BrF3
Molecular Weight	224.99 g/mol
Synonyms	2-Bromo-α,α-difluoro-6-fluorotoluene; 3-Fluoro-2-(difluoromethyl)bromobenzene; 1-Bromo-2-(difluoromethyl)-3-fluorobenzene; 2-(Difluoromethyl)-3-fluorobromobenzene; Benzene, 1-bromo-2-(difluoromethyl)-3-fluoro-; 1166820-46-7
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(Difluoromethyl)-3-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density	~1.7 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.