Description

(5E)-Bimatoprost CAS NO 1163135-95-2 is a synthetic prostaglandin analog and a key pharmaceutical intermediate of significant commercial and therapeutic value. It is a stereoisomer of the active pharmaceutical ingredient Bimatoprost, which is widely recognized for its efficacy in treating glaucoma and promoting eyelash growth. This high-purity compound is essential for research, development, and manufacturing within the global pharmaceutical and biotechnology sectors, where precise chemical identity and quality are paramount.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: A critical intermediate in the production of Bimatoprost-based ophthalmic solutions for glaucoma and ocular hypertension.
• Research & Development: Used in preclinical and clinical studies to investigate the pharmacological properties of prostaglandin analogs.
• Cosmetic & Dermatological Formulations: Serves as a precursor in the development of products aimed at enhancing eyelash growth and thickness.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and manufacturing processes for prostaglandin-based therapeutics.
• Analytical Reference Standard: Utilized as a high-purity standard in quality control laboratories for HPLC, LC-MS, and other analytical methods.
• Biochemical Research: A tool compound for studying prostaglandin receptors (FP receptors) and related signaling pathways.

Basic Information

Product Name	(5E)-Bimatoprost
CAS No.	1163135-95-2
Molecular Formula	C25H37NO4
Molecular Weight	415.57 g/mol
Synonyms	(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-5-heptenamide; (5E)-Isomer of Bimatoprost; Bimatoprost Impurity; Bimatoprost Related Compound; Prostaglandin F2α Ethanolamide Analog; AGN 192024 (5E)-Isomer; Lumigan® Related Compound
EINECS	Contact for details

Quality Control

Our (5E)-Bimatoprost is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Assay (on dried basis)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.