Description

(15R)-Bimatoprost CAS NO 1163135-92-9 is a stereoisomer of the synthetic prostaglandin analog bimatoprost, distinguished by its specific configuration at the 15-position. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential in creating novel therapeutic agents. It is primarily sought after by pharmaceutical manufacturers and research institutions focused on ophthalmology, dermatology, and prostaglandin-based drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel prostaglandin F2α analogs for clinical research.
• Ophthalmic Drug Development: Investigated for potential applications in glaucoma treatment and eyelash growth enhancement, similar to its parent compound.
• Dermatological Research: Used in studies exploring the effects of specific prostaglandin isomers on hair follicle stimulation and skin cell proliferation.
• Chemical Reference Standard: Employed as a high-purity standard in analytical laboratories for method development, validation, and quality control of bimatoprost-based products.
• Mechanistic Studies: Utilized in pharmacological research to understand the structure-activity relationship (SAR) and receptor binding specificity of prostaglandin analogs.
• Process Chemistry: Acts as a critical intermediate in the development and optimization of stereoselective synthetic routes for complex active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	(15R)-Bimatoprost
CAS No.	1163135-92-9
Molecular Formula	C25H37NO4
Molecular Weight	415.57 g/mol
Synonyms	(15R)-7-[3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-5-heptenoic acid N-ethylamide; (15R)-Bimatoprost; (15R)-Isomer of Bimatoprost; AGN 192024 (15R-isomer); Lumigan® (related isomer); Prostaglandin F2α analog (15R)
EINECS	Contact for details

Quality Control

Our (15R)-Bimatoprost is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, identity confirmation by IR and NMR spectroscopy, and stringent control of related substances. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (15R-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.