Description

Mcb-613 is a high-purity specialty chemical identified by CAS NO 1162656-22-5, widely employed as a critical intermediate in the synthesis of advanced pharmaceuticals and functional materials. Its structural precision and batch-to-batch consistency enable reliable performance in demanding reaction pathways where impurity control directly impacts final product efficacy and regulatory compliance. This compound is essential for R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical manufacturers focused on oncology therapeutics, kinase inhibitors, and next-generation agrochemical actives.

Application

• Key synthetic intermediate in the production of tyrosine kinase inhibitors (e.g., analogues of erlotinib and gefitinib)
• Building block for phosphatase-targeted drug candidates in neurodegenerative disease research
• Component in the preparation of photoactive prodrugs requiring controlled release under UV-triggered conditions
• Reagent in metal-catalyzed cross-coupling reactions (Suzuki, Buchwald–Hartwig) for heterocyclic API synthesis
• Functional modifier in high-performance polymer precursors for optoelectronic applications
• Reference standard in LC-MS/MS method development for bioanalytical assay validation

Basic Information

Product Name	Mcb-613
CAS No.	1162656-22-5
Molecular Formula	C18H17ClN4O3
Molecular Weight	372.81 g/mol
Synonyms	MCB-613; (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-chlorophenyl)propanoic acid; Boc-L-4-chlorophenylglycine; N-[(1S)-1-Carboxy-2-(4-chlorophenyl)ethyl]carbamic acid tert-butyl ester; Boc-(S)-4-Cl-Phe-OH; tert-Butyl ((S)-1-carboxy-2-(4-chlorophenyl)ethyl)carbamate; (S)-N-Boc-4-chlorophenylglycine; Boc-S-4-Cl-Phg-OH
EINECS	452-980-0

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to ACS Reagent Grade specifications and meet ICH Q7 guidelines for pharmaceutical intermediates. Testing includes identity confirmation (IR, HPLC retention time matching), assay (HPLC area normalization), residual solvents (GC-FID), heavy metals (USP <231>), and chiral purity (Chiral HPLC). Full traceability and stability data are provided per batch.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccant packs during long-term storage. Avoid repeated opening of containers and maintain under inert gas (nitrogen or argon) when possible.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 99.0%
Specific Rotation [α]D20	–15.0° to –17.5° (c = 1 in DMF)
Water (KF)	≤ 0.5%
Residual Solvents (GC)	MeOH ≤ 3000 ppm; EtOAc ≤ 5000 ppm; Heptane ≤ 5000 ppm
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.