Description

Pde4 (R)-(-)-Rolipram is a high-purity, enantiomerically pure chemical compound used as a potent and selective inhibitor of phosphodiesterase 4 (PDE4). This compound matters for its critical role in biochemical and pharmacological research, particularly in the study of inflammatory pathways and central nervous system disorders. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in developing novel therapeutics for conditions like depression, asthma, and chronic obstructive pulmonary disease (COPD).

Application

• Pharmaceutical Research & Development: A key reference standard and active tool compound for studying PDE4 enzyme inhibition and its downstream effects.
• Neuropharmacology Studies: Used in preclinical research to investigate mechanisms related to memory, learning, depression, and neurodegenerative diseases.
• Inflammation & Immunology Research: Employed as a selective agent to modulate cAMP levels in immune cells, aiding in the study of asthma, psoriasis, and other inflammatory conditions.
• Biochemical Assay Development: Serves as a critical control and validation compound in high-throughput screening (HTS) assays for PDE4 target engagement.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies on cyclic nucleotide signaling pathways.
• Reference Standard for Analytical Labs: Provides a certified material for method development, calibration, and quality control in analytical testing (e.g., HPLC, LC-MS).

Basic Information

Product Name	Pde4 (R)-(-)-Rolipram
CAS No.	1160521-50-5
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.34 g/mol
Synonyms	(R)-(-)-Rolipram; (R)-Rolipram; (-)-Rolipram; Rolipram, (R)-(-)-; PDE4 Inhibitor (R)-(-)-Rolipram; 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, (R)-; (3R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
EINECS	Contact for details

Quality Control

Our Pde4 (R)-(-)-Rolipram is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment to guarantee reproducible and reliable research results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.