Description

2-Hydroxy-4-Methyl-6-Quinolinesulfonyl Chloride (Saltdata: Free) is a specialized sulfonyl chloride derivative of a hydroxyquinoline, serving as a critical building block in advanced organic synthesis. This compound is valued for its reactive sulfonyl chloride group, which enables the efficient introduction of the sulfonamide moiety into target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly those targeting enzymes where sulfonamide groups are pharmacologically active.
• Agrochemical Research: Used in creating novel herbicides, fungicides, or insecticides by incorporating the quinoline-sulfonamide scaffold.
• Material Science: Building block for designing functional polymers or metal-organic frameworks (MOFs) with specific ligating or catalytic properties.
• Chemical Biology Probe Development: Useful for synthesizing activity-based probes or affinity labels to study biological pathways and protein function.
• Dye and Pigment Synthesis: Intermediate in the production of specialized quinoline-based dyes and colorants.

Basic Information

Product Name	2-Hydroxy-4-Methyl-6-Quinolinesulfonyl Chloride (Saltdata: Free)
CAS No.	1160370-78-4
Molecular Formula	C10H8ClNO3S
Molecular Weight	257.69 g/mol
Synonyms	6-(Chlorosulfonyl)-4-methyl-2-quinolinol; 4-Methyl-2-hydroxy-6-quinolinesulfonyl chloride; 2-Hydroxy-4-methylquinoline-6-sulfonyl chloride; 4-Methyl-2-oxo-1,2-dihydroquinoline-6-sulfonyl chloride; Quinoline-6-sulfonyl chloride, 2-hydroxy-4-methyl-; (2-Hydroxy-4-methylquinolin-6-yl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4-Methyl-6-Quinolinesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in common organic solvents (DMF, DMSO, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.