Description

n-Arachidonoyl Dopamine-D8 is a deuterated analog of the endogenous endocannabinoid n-arachidonoyl dopamine (NADA), a potent ligand for the TRPV1 receptor and CB1 cannabinoid receptor. This stable isotope-labeled compound is essential for quantitative mass spectrometry-based analysis, providing unparalleled accuracy in pharmacokinetic and metabolic studies. It is a critical tool for researchers and analytical laboratories in the pharmaceutical, biotechnology, and neuroscience sectors who require high-purity reference standards for method development and validation.

Application

• Internal Standard for LC-MS/MS: Serves as a quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays for the accurate measurement of endogenous NADA levels in biological matrices.
• Metabolic Pathway Research: Used to trace and elucidate the metabolic pathways and biotransformation products of n-arachidonoyl dopamine in vitro and in vivo.
• Pharmacokinetic (PK) Studies: Enables precise determination of absorption, distribution, metabolism, and excretion (ADME) profiles for related drug candidates targeting the endocannabinoid system.
• Biomarker Discovery & Validation: Facilitates the development and validation of sensitive analytical methods for NADA as a potential biomarker in neurological and inflammatory conditions.
• Quality Control Reference: Acts as a certified reference material (CRM) for the quality control and standardization of assays in diagnostic and research settings.
• Neuropharmacology Research: Supports fundamental research into the role of endocannabinoids in pain sensation, neuroprotection, and synaptic plasticity.

Basic Information

Product Name	n-Arachidonoyl Dopamine-D8
CAS No.	1159908-42-5
Molecular Formula	C26H31D8NO3
Molecular Weight	~413.6 g/mol
Synonyms	NADA-d8; N-Arachidonoyldopamine-d8; Arachidonoyl dopamine-d8; (5Z,8Z,11Z,14Z)-N-(2-(3,4-Dihydroxyphenyl)ethyl)icosa-5,8,11,14-tetraenamide-d8; N-(2-Aminoethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide-d8; Endocannabinoid NADA-d8; NADA Internal Standard; Deuterated NADA
EINECS	Contact for details

Quality Control

Our n-Arachidonoyl Dopamine-D8 is manufactured under strict quality protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98% D), chemical purity (≥95% by HPLC), and analytical data is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.