Description

Aurora A Inhibitor I CAS NO 1158838-45-9 is a potent and selective small molecule inhibitor of the Aurora A kinase, a key regulator of cell cycle progression and mitosis. This compound is a critical research tool for investigating mitotic spindle assembly, centrosome maturation, and the role of Aurora A in oncogenesis. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cancer biology, kinase signaling pathways, and preclinical drug discovery.

Application

• Biochemical Research: Used as a selective probe to study Aurora A kinase function and its downstream signaling cascades in vitro.
• Cell Biology Studies: Applied in cell-based assays to investigate the effects of Aurora A inhibition on cell cycle arrest, apoptosis, and aneuploidy.
• Cancer Research & Target Validation: Serves as a critical tool for validating Aurora A as a therapeutic target in various cancer models, including breast, pancreatic, and ovarian cancers.
• High-Throughput Screening (HTS): Employed as a reference compound or positive control in screening campaigns to identify novel Aurora A inhibitors.
• Preclinical Drug Development: Used to establish proof-of-concept and benchmark the efficacy of new drug candidates in oncology research pipelines.
• Mechanistic Studies: Facilitates research into centrosome amplification, spindle pole integrity, and mitotic checkpoint regulation.

Basic Information

Product Name	Aurora A Inhibitor I
CAS No.	1158838-45-9
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	MLN8054; Aurora A Kinase Inhibitor I; 4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic Acid; Benzoic acid, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-; Aurora A Inhibitor (MLN8054); MLN 8054; Aurora Kinase A Inhibitor MLN8054
EINECS	Contact for details

Quality Control

Our Aurora A Inhibitor I is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure high batch-to-batch consistency and reliability for research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.