Description

Aurora A Inhibitor II is a potent and selective small-molecule inhibitor of the Aurora A kinase, a key regulator of mitotic progression. This compound is a critical research tool for investigating cell cycle dynamics, centrosome maturation, and spindle assembly, with significant implications for oncology research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in cancer biology studies and preclinical drug discovery programs.

Application

• Biochemical Research: Used as a selective probe to study the specific biological functions and signaling pathways of Aurora A kinase in vitro.
• Cancer Mechanism Studies: Essential for investigating the role of Aurora A in tumorigenesis, aneuploidy, and cancer cell proliferation.
• High-Throughput Screening (HTS): Serves as a reference standard or positive control in cell-based and biochemical assays for kinase inhibitor discovery.
• Preclinical Development: A valuable tool compound for evaluating the therapeutic potential of Aurora A inhibition in animal models of cancer.
• Cell Cycle Analysis: Employed to induce mitotic arrest and study checkpoint mechanisms, spindle pole defects, and polyploidy in cultured cells.

Basic Information

Product Name	Aurora A Inhibitor II
CAS No.	1158838-43-7
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	MLN8054; 4-[[9-Chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid; Aurora A Kinase Inhibitor II; Aurora A Inhibitor MLN8054; Benzoic acid, 4-[[9-chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-; 4-({9-Chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl}amino)benzoic acid
EINECS	Contact for details

Quality Control

Our Aurora A Inhibitor II is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and reproducible biological activity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.