Description

6-Chloro-4-(Trifluoromethyl)Picolinonitrile is a high-purity, multi-functional chemical building block. This compound is valued for its unique trifluoromethyl and chloro-substituted pyridine core, which imparts significant electronic and steric properties for advanced synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients. Its specific structure makes it a critical intermediate in the development of new compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers in the development of specialty polymers and advanced materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes and tool compounds to study biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	6-Chloro-4-(Trifluoromethyl)Picolinonitrile
CAS No.	1156542-25-4
Molecular Formula	C7H2ClF3N2
Molecular Weight	206.55 g/mol
Synonyms	6-Chloro-4-(trifluoromethyl)pyridine-2-carbonitrile; 2-Cyano-6-chloro-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-6-chloropicolinonitrile; 6-Chloro-4-trifluoromethylpicolinonitrile; 6-Chloro-4-(trifluoromethyl)-2-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-(Trifluoromethyl)Picolinonitrile is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring high standards, including cGMP development and commercial-scale production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect product stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.