Description

3-Bromo-4-Difluoromethoxybenzaldehyde is a high-purity aromatic aldehyde building block, distinguished by its bromine and difluoromethoxy substituents which impart unique electronic and steric properties. This compound is critical for advanced organic synthesis, enabling the precise construction of complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the difluoromethoxy group can enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for advanced electronic materials, where its halogenated structure contributes to desired dielectric and luminescent properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological processes and protein interactions.
• Polymer & Resin Modifier: Incorporated into specialty polymers to modify thermal stability, solubility, and other physical characteristics.

Basic Information

Product Name	3-Bromo-4-Difluoromethoxybenzaldehyde
CAS No.	1155878-02-6
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	4-(Difluoromethoxy)-3-bromobenzaldehyde; 3-Bromo-4-(difluoromethoxy)benzaldehyde; Benzaldehyde, 3-bromo-4-(difluoromethoxy)-; 1155878-02-6
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Difluoromethoxybenzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.