Description

Cytochrome P450 14A-Demethylase Inhibitor 1N is a potent and selective small molecule inhibitor targeting the CYP51 enzyme, a key component in sterol biosynthesis. This compound is critical for researchers investigating fungal biology, parasitic infections, and cholesterol metabolism pathways. It is primarily utilized by pharmaceutical R&D teams, academic institutions, and biotechnology companies focused on developing novel antifungal agents and studying sterol-related diseases.

Application

• Antifungal Research: Serves as a key biochemical tool for studying the inhibition of ergosterol synthesis in pathogenic fungi, aiding in the discovery of new therapeutic candidates.
• Parasitology Studies: Used in research targeting Trypanosoma and Leishmania parasites, where CYP51 is essential for their survival, facilitating drug development for neglected tropical diseases.
• Sterol Biosynthesis Pathway Analysis: Enables precise interrogation of the lanosterol 14α-demethylase step in eukaryotic cells, valuable for fundamental cell biology and metabolic research.
• High-Throughput Screening (HTS): Employed as a reference compound or positive control in assay development and screening campaigns for CYP51 inhibitor identification.
• Biochemical Assay Development: Provides a validated inhibitor for enzyme kinetic studies, IC50 determination, and mechanism-of-action investigations.
• Veterinary Medicine Research: Applied in studies aimed at developing treatments for fungal infections in animals and livestock.

Basic Information

Product Name	Cytochrome P450 14A-Demethylase Inhibitor 1N
CAS No.	1155361-12-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CYP51 Inhibitor 1N; Lanosterol 14-alpha Demethylase Inhibitor 1N; Sterol 14α-Demethylase Inhibitor; (2-Phenyl-1,2,3-triazol-4-yl)methyl 4-(4-chlorophenyl)piperazine-1-carbodithioate; 1N Inhibitor; CYP51A1 Inhibitor; Antifungal Research Compound 1N; CAS 1155361-12-8
EINECS	Contact for details

Quality Control

Our Cytochrome P450 14A-Demethylase Inhibitor 1N is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation, to ensure high batch-to-batch consistency and reliability for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.